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Let's say we're given this differential equation that we can't solve (with our current methods).
$$\dfrac{dy}{dx} = f(x,y)$$
We want to rewrite the equation in terms of a different variable, $v$. So, we do a substitution, like $v = x + y$, although it can be anything. Now, we rewrite it in terms of y,$y = \phi(x,v)$, and take the derivative with respect to x. The next step is done with the multivariable chain rule.
$$\dfrac{dy}{dx} = \phi_x(x,v)\dfrac{dx}{dx} + \phi_v(x,v)\dfrac{dv}{dx} = \boxed{\phi_x(x,v) + \phi_v(x,v)\dfrac{dv}{dx}}$$
So, we set the two expressions for $\frac{dy}{dx}$, and then we're guaranteed to be able to solve the equation. This is because we are only doing a few substitutions, $v = ax + by + c$, $v = \frac{y}{x}$, and $v = y^{1 - n}$. We proved that using each substitution gives you a separable or first-order linear equation.